As one of the core technologies in precision medicine, NGS-based liquid biopsy has been widely used in clinical practice. Efficient extraction and purification of cfDNA is a solid foundation to ensure accurate and reliable test results. However, due to the extremely low concentration of target cfDNA in plasma and the complexity of biological samples, it is difficult to efficiently extract and purify cfDNA. VDO Biotech has specially developed cfDNA extraction magnetic microspheres for plasma samples to help improve the efficiency and accuracy of liquid biopsy.

Features:

• Large specific surface area, strong binding capacity 

• Super paramagnetic microspheres, excellent resuspension performance 

• Special surface modification, strong nucleic acid adsorption capacity and easy elution 

• Fast magnetic response and magnetic absorption, no magnetic residue 

• Large-scale production capacity is up to >100 L/batch, batch-to-batch consistency ensures high reproducibility

Case study of cfDNA extraction using magnetic microspheres:

Compared with Company A and B, the cfDNA extracted by VDO magnetic microspheres is superior in both yield and purity (using Qubit quantification, Agilent Bioanalyzer 2100 for fragment analysis)

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